منابع مشابه
Ion channels and neurology.
Rapid communication between cells is dependent on electrical signals produced by the passage of charged ions through specialised proteins embedded in cell membranes. These ion channels have been essential to the health and survival of organisms since life began. One might therefore expect that diseases of ion channels or channelopathies would not be compatible with life. The past decade has sho...
متن کاملIon selectivity and current saturation in inward-rectifier K+ channels
We investigated the features of the inward-rectifier K channel Kir1.1 (ROMK) that underlie the saturation of currents through these channels as a function of permeant ion concentration. We compared values of maximal currents and apparent K(m) for three permeant ions: K(+), Rb(+), and NH(4)(+). Compared with K(+) (i(max) = 4.6 pA and K(m) = 10 mM at -100 mV), Rb(+) had a lower permeability, a lo...
متن کاملO 13: Ion Channels in Autoimmune Neurodegeneration
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by widespread inflammation, focal demyelination and a variable degree of axonal and neuronal loss. Ionic conductances regulate T cell activation as well as neuronal function and thus have been found to play a crucial role in MS pathogenesis. Since present therapeutical approaches are only parti...
متن کاملMulti-ion versus single-ion conduction mechanisms can yield current rectification in biological ion channels.
There is clear evidence that the net magnitude of negative charge at the intracellular end of inwardly rectifying potassium channels helps to generate an asymmetry in the magnitude of the current that will pass in each direction. However, a complete understanding of the physical mechanism that links these charges to current rectification has yet to be obtained. Using Brownian dynamics, we compa...
متن کاملModulation of Ion Channels A “Current” View of AKAPs
Vollum Institute sites on AKAPs have been used to establish a role for Oregon Health Sciences University these proteins in functional coupling to a variety of ion Portland, Oregon 97201 channels. Many of these studies were made possible by the development of an anchoring inhibitor peptide derived from the RII binding site of an AKAP (Ht31), Deciphering the molecular organization of synapses and...
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ژورنال
عنوان ژورنال: Archives of Disease in Childhood
سال: 2001
ISSN: 0003-9888
DOI: 10.1136/adc.84.3.277